Chemical screening platforms for autophagy drug discovery to identify therapeutic candidates for Huntington's disease and other neurodegenerative disorders
S Sarkar - Drug Discovery Today: Technologies, 2013 - Elsevier
Autophagy is a cellular degradation process involved in the clearance of aggregate-prone
proteins associated with neurodegenerative diseases. While the mTOR pathway has been
known to be the major regulator of autophagy, recent advancements into the regulation of
autophagy have identified mTOR-independent autophagy pathways that are amenable to
chemical perturbations. Several chemical and genetic screens have been undertaken to
identify small molecule and genetic regulators of autophagy, respectively. The small …
proteins associated with neurodegenerative diseases. While the mTOR pathway has been
known to be the major regulator of autophagy, recent advancements into the regulation of
autophagy have identified mTOR-independent autophagy pathways that are amenable to
chemical perturbations. Several chemical and genetic screens have been undertaken to
identify small molecule and genetic regulators of autophagy, respectively. The small …