Cellular energy influences all aspects of cellular function. Although cells can adapt to a
gradual reduction in energy, acute energy depletion poses a unique challenge. Because
acute depletion hampers the transport of new energy sources into the cell, the cell must use
endogenous substrates to replenish energy after acute depletion. In the yeast
Saccharomyces cerevisiae, glucose starvation causes an acute depletion of intracellular
energy that recovers during continued glucose starvation. However, how the cell …