Autophagy in the brains of young patients with poorly controlled T1DM and fatal diabetic ketoacidosis
WH Hoffman, JJ Shacka, AV Andjelkovic - Experimental and molecular …, 2012 - Elsevier
Semi-quantitative neuroradiologic studies, quantitative neuron density studies and
immunocytochemistry markers of oxidative stress and neuroinflammation indicate neuronal
injury and deficits in young patients with chronic poorly controlled type 1 diabetes mellitus
(T1DM). Present data suggest that pathogenesis of the neuronal deficits in young patients,
who die as the result of diabetic ketoacidosis (DKA) and brain edema (BE), does not involve
apoptosis, a prominent form of regulated cell death in many disease states. To further …
immunocytochemistry markers of oxidative stress and neuroinflammation indicate neuronal
injury and deficits in young patients with chronic poorly controlled type 1 diabetes mellitus
(T1DM). Present data suggest that pathogenesis of the neuronal deficits in young patients,
who die as the result of diabetic ketoacidosis (DKA) and brain edema (BE), does not involve
apoptosis, a prominent form of regulated cell death in many disease states. To further …