The subcellular distribution of GABARAP and its ability to interact with NSF suggest a role for this protein in the intracellular transport of GABAA receptors
GABAA receptors the major sites of fast synaptic inhibition in the brain are composed
predominately of α, β, and γ2 subunits. The receptor γ2 subunit interacts with a 17-kDa
microtubule associated protein GABARAP, but the significance of this interaction remains
unknown. Here we demonstrate that GABARAP, which immunoprecipitates with GABAA
receptors, is not found at significant levels within inhibitory synapses, but is enriched within
the Golgi apparatus and postsynaptic cisternae. We also demonstrate that GABARAP binds …
predominately of α, β, and γ2 subunits. The receptor γ2 subunit interacts with a 17-kDa
microtubule associated protein GABARAP, but the significance of this interaction remains
unknown. Here we demonstrate that GABARAP, which immunoprecipitates with GABAA
receptors, is not found at significant levels within inhibitory synapses, but is enriched within
the Golgi apparatus and postsynaptic cisternae. We also demonstrate that GABARAP binds …