[HTML][HTML] Differential function of the two Atg4 homologues in the aggrephagy pathway in Caenorhabditis elegans
The presence of multiple homologues of the same yeast Atg protein endows an additional
layer of complexity on the autophagy pathway in higher eukaryotes. The physiological
function of the individual genes, however, remains largely unknown. Here we investigated
the role of the two Caenorhabditis elegans homologues of the cysteine protease Atg4 in the
pathway responsible for degradation of protein aggregates. Loss of atg-4.1 activity causes
defective degradation of a variety of protein aggregates, whereas atg-4.2 mutants remove …
layer of complexity on the autophagy pathway in higher eukaryotes. The physiological
function of the individual genes, however, remains largely unknown. Here we investigated
the role of the two Caenorhabditis elegans homologues of the cysteine protease Atg4 in the
pathway responsible for degradation of protein aggregates. Loss of atg-4.1 activity causes
defective degradation of a variety of protein aggregates, whereas atg-4.2 mutants remove …