[HTML][HTML] Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy
G Marino, JA Urıa, XS Puente, V Quesada… - Journal of Biological …, 2003 - ASBMB
We have cloned four human cDNAs encoding putative cysteine proteinases that have been
tentatively called autophagins. These proteins are similar to Apg4/Aut2, a yeast enzyme
involved in the activation of Apg8/Aut7 during the process of autophagy. The identified
proteins ranging in length from 393 to 474 amino acids also contain several structural
features characteristic of cysteine proteinases including a conserved cysteine residue that is
essential for the catalytic properties of these enzymes. Northern blot analysis demonstrated …
tentatively called autophagins. These proteins are similar to Apg4/Aut2, a yeast enzyme
involved in the activation of Apg8/Aut7 during the process of autophagy. The identified
proteins ranging in length from 393 to 474 amino acids also contain several structural
features characteristic of cysteine proteinases including a conserved cysteine residue that is
essential for the catalytic properties of these enzymes. Northern blot analysis demonstrated …