[HTML][HTML] Roles of the lipid-binding motifs of Atg18 and Atg21 in the cytoplasm to vacuole targeting pathway and autophagy
U Nair, Y Cao, Z Xie, DJ Klionsky - Journal of Biological Chemistry, 2010 - ASBMB
Atg18 and Atg21 are homologous WD-40 repeat proteins that bind phosphoinositides via a
novel conserved Phe-Arg-Arg-Gly motif and function in autophagy-related pathways. Atg18
is required for the cytoplasm to vacuole targeting (Cvt) pathway and autophagy, whereas
Atg21 is only required for the Cvt pathway. Currently, the functions of both proteins are
poorly understood. Here, we examined the relationship between the phosphatidylinositol 3-
phosphate (PtdIns (3) P)-binding abilities of Atg18 and Atg21 and autophagy by expressing …
novel conserved Phe-Arg-Arg-Gly motif and function in autophagy-related pathways. Atg18
is required for the cytoplasm to vacuole targeting (Cvt) pathway and autophagy, whereas
Atg21 is only required for the Cvt pathway. Currently, the functions of both proteins are
poorly understood. Here, we examined the relationship between the phosphatidylinositol 3-
phosphate (PtdIns (3) P)-binding abilities of Atg18 and Atg21 and autophagy by expressing …