[HTML][HTML] p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways
Autophagy is an important mechanism of innate immune defense. We have recently shown
that autophagy components are recruited with septins, a new and increasingly characterized
cytoskeleton component, to intracytosolic Shigella that have started to polymerize actin. On
the other hand, intracytosolic Listeria avoids autophagy recognition by expressing ActA, a
bacterial effector required for actin polymerization. Here, we exploit Shigella and Listeria as
intracytosolic tools to characterize different pathways of selective autophagy. We show that …
that autophagy components are recruited with septins, a new and increasingly characterized
cytoskeleton component, to intracytosolic Shigella that have started to polymerize actin. On
the other hand, intracytosolic Listeria avoids autophagy recognition by expressing ActA, a
bacterial effector required for actin polymerization. Here, we exploit Shigella and Listeria as
intracytosolic tools to characterize different pathways of selective autophagy. We show that …