[HTML][HTML] PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding
L Wang, TE Harris, RA Roth, JC Lawrence - Journal of Biological Chemistry, 2007 - ASBMB
Mammalian target of rapamycin (mTOR) functions in two distinct signaling complexes,
mTORC1 and mTORC2. In response to insulin and nutrients, mTORC1, consisting of mTOR,
raptor (regulatory-associated protein of mTOR), and mLST8, is activated and phosphorylates
eukaryotic initiation factor 4E-binding protein (4EBP) and p70 S6 kinase to promote protein
synthesis and cell size. Previously we found that activation of mTOR kinase in response to
insulin was associated with increased 4EBP1 binding to raptor. Here we identify prolinerich …
mTORC1 and mTORC2. In response to insulin and nutrients, mTORC1, consisting of mTOR,
raptor (regulatory-associated protein of mTOR), and mLST8, is activated and phosphorylates
eukaryotic initiation factor 4E-binding protein (4EBP) and p70 S6 kinase to promote protein
synthesis and cell size. Previously we found that activation of mTOR kinase in response to
insulin was associated with increased 4EBP1 binding to raptor. Here we identify prolinerich …