Common human Toll-like receptor 4 polymorphisms—role in susceptibility to respiratory syncytial virus infection and functional immunological relevance
SC Paulus, AF Hirschfeld, RE Victor, J Brunstein… - Clinical …, 2007 - Elsevier
Evidence suggests that Toll-like receptor 4 (TLR4) contributes to immune recognition of
respiratory syncytial virus (RSV). The TLR4 gene harbours a polymorphism–Asp299Gly–
previously associated with reduced TLR4 signalling. To understand of how host genetic
variation influences the outcome of RSV infection in children, we examined the association
between the TLR4 299Gly allele and severe RSV disease. By genotyping 236 children with
RSV infection and 219 healthy controls we found no association between the risk of severe …
respiratory syncytial virus (RSV). The TLR4 gene harbours a polymorphism–Asp299Gly–
previously associated with reduced TLR4 signalling. To understand of how host genetic
variation influences the outcome of RSV infection in children, we examined the association
between the TLR4 299Gly allele and severe RSV disease. By genotyping 236 children with
RSV infection and 219 healthy controls we found no association between the risk of severe …