[HTML][HTML] Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression
BA Carlson, MH Yoo, Y Sano, A Sengupta, JY Kim… - BMC immunology, 2009 - Springer
BMC immunology, 2009•Springer
Background Selenium, a micronutrient whose deficiency in diet causes immune dysfunction
and inflammatory disorders, is thought to exert its physiological effects mostly in the form of
selenium-containing proteins (selenoproteins). Incorporation of selenium into the amino acid
selenocysteine (Sec), and subsequently into selenoproteins is mediated by Sec tRNA [Ser]
Sec. Results To define macrophage-specific selenoprotein functions, we generated mice
with the Sec tRNA [Ser] Sec gene specifically deleted in myeloid cells. These mutant mice …
and inflammatory disorders, is thought to exert its physiological effects mostly in the form of
selenium-containing proteins (selenoproteins). Incorporation of selenium into the amino acid
selenocysteine (Sec), and subsequently into selenoproteins is mediated by Sec tRNA [Ser]
Sec. Results To define macrophage-specific selenoprotein functions, we generated mice
with the Sec tRNA [Ser] Sec gene specifically deleted in myeloid cells. These mutant mice …
Background
Selenium, a micronutrient whose deficiency in diet causes immune dysfunction and inflammatory disorders, is thought to exert its physiological effects mostly in the form of selenium-containing proteins (selenoproteins). Incorporation of selenium into the amino acid selenocysteine (Sec), and subsequently into selenoproteins is mediated by Sec tRNA[Ser]Sec.
Results
To define macrophage-specific selenoprotein functions, we generated mice with the Sec tRNA[Ser]Sec gene specifically deleted in myeloid cells. These mutant mice were devoid of the "selenoproteome" in macrophages, yet exhibited largely normal inflammatory responses. However, selenoprotein deficiency led to aberrant expression of extracellular matrix-related genes, and diminished migration of macrophages in a protein gel matrix.
Conclusion
Selenium status may affect immune defense and tissue homeostasis through its effect on selenoprotein expression and the trafficking of tissue macrophages.
Springer
