Hydrophobic surfactant proteins in lung function and disease
JA Whitsett, TE Weaver - New England Journal of Medicine, 2002 - Mass Medical Soc
JA Whitsett, TE Weaver
New England Journal of Medicine, 2002•Mass Medical SocPulmonary surfactants consist of phospholipids and the hydrophobic proteins surfactant
protein B and surfactant protein C. These surfactants keep the alveoli in the lung open to the
atmosphere. Mutations in the genes encoding these proteins cause a variety of pulmonary
syndromes. The pulmonary diseases associated with some of these mutations exemplify the
consequences of the accumulation of misfolded proteins in tissue.
protein B and surfactant protein C. These surfactants keep the alveoli in the lung open to the
atmosphere. Mutations in the genes encoding these proteins cause a variety of pulmonary
syndromes. The pulmonary diseases associated with some of these mutations exemplify the
consequences of the accumulation of misfolded proteins in tissue.
Pulmonary surfactants consist of phospholipids and the hydrophobic proteins surfactant protein B and surfactant protein C. These surfactants keep the alveoli in the lung open to the atmosphere. Mutations in the genes encoding these proteins cause a variety of pulmonary syndromes. The pulmonary diseases associated with some of these mutations exemplify the consequences of the accumulation of misfolded proteins in tissue.
The New England Journal Of Medicine