Local application of platelet-activating factor induces cervical ripening accompanied by infiltration of polymorphonuclear leukocytes in rats
H Maul, L Shi, SG Marx, RE Garfield… - American journal of …, 2002 - Elsevier
Objective: The purpose of this study was to determine the effect of locally applied platelet-
activating factor on cervical ripening and leukocyte infiltration. Study Design: Timed-
pregnant rats were treated vaginally twice each day on days 14 and 15 of gestation with
platelet-activating factor 5× 10− 8 mol/L (low-dose), 5× 10− 7 mol/L (high-dose), or solvent
and were killed on day 16. Cervical ripening was assessed by cervical resistance-to-stretch
and light-induced autofluorescence of cross-linked collagen. Longitudinal sections of the …
activating factor on cervical ripening and leukocyte infiltration. Study Design: Timed-
pregnant rats were treated vaginally twice each day on days 14 and 15 of gestation with
platelet-activating factor 5× 10− 8 mol/L (low-dose), 5× 10− 7 mol/L (high-dose), or solvent
and were killed on day 16. Cervical ripening was assessed by cervical resistance-to-stretch
and light-induced autofluorescence of cross-linked collagen. Longitudinal sections of the …