The SLAM and SAP gene families control innate and adaptive immune responses
S Calpe, N Wang, X Romero, SB Berger, A Lanyi… - Advances in …, 2008 - Elsevier
The nine SLAM‐family genes, SLAMF1–9, a subfamily of the immunoglobulin superfamily,
encode differentially expressed cell‐surface receptors of hematopoietic cells. Engagement
with their ligands, which are predominantly homotypic, leads to distinct signal transduction
events, for instance those that occur in the T or NK cell immune synapse. Upon
phosphorylation of one or more copies of a unique tyrosine‐based signaling motif in their
cytoplasmic tails, six of the SLAM receptors recruit the highly specific single SH2‐domain …
encode differentially expressed cell‐surface receptors of hematopoietic cells. Engagement
with their ligands, which are predominantly homotypic, leads to distinct signal transduction
events, for instance those that occur in the T or NK cell immune synapse. Upon
phosphorylation of one or more copies of a unique tyrosine‐based signaling motif in their
cytoplasmic tails, six of the SLAM receptors recruit the highly specific single SH2‐domain …
