[HTML][HTML] Basic fibroblast growth factor activates the MAPK and NFκB pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human …
The pathology of joint destruction is associated with elevated production of basic fibroblast
growth factor (bFGF) and matrix metalloproteinase-13 (MMP-13). In osteoarthritic joint
disease, expression of bFGF and MMP-13 in chondrocytes and their release into the
synovial fluid are significantly increased. We have previously found that the capacity for
cartilage repair in human adult articular chondrocytes is severely compromised by minimal
exposure to bFGF because bFGF reduces responsiveness to bone morphogenetic protein-7 …
growth factor (bFGF) and matrix metalloproteinase-13 (MMP-13). In osteoarthritic joint
disease, expression of bFGF and MMP-13 in chondrocytes and their release into the
synovial fluid are significantly increased. We have previously found that the capacity for
cartilage repair in human adult articular chondrocytes is severely compromised by minimal
exposure to bFGF because bFGF reduces responsiveness to bone morphogenetic protein-7 …