[HTML][HTML] Cellular and molecular basis of wound healing in diabetes
H Brem, M Tomic-Canic - The Journal of clinical …, 2007 - Am Soc Clin Investig
H Brem, M Tomic-Canic
The Journal of clinical investigation, 2007•Am Soc Clin InvestigDiabetic foot ulcers (DFUs), a leading cause of amputations, affect 15% of people with
diabetes. A series of multiple mechanisms, including decreased cell and growth factor
response, lead to diminished peripheral blood flow and decreased local angiogenesis, all of
which can contribute to lack of healing in persons with DFUs. In this issue of the JCI,
Gallagher and colleagues demonstrate that in diabetic mice, hyperoxia enhances the
mobilization of circulating endothelial progenitor cells (EPCs) from the bone marrow to the …
diabetes. A series of multiple mechanisms, including decreased cell and growth factor
response, lead to diminished peripheral blood flow and decreased local angiogenesis, all of
which can contribute to lack of healing in persons with DFUs. In this issue of the JCI,
Gallagher and colleagues demonstrate that in diabetic mice, hyperoxia enhances the
mobilization of circulating endothelial progenitor cells (EPCs) from the bone marrow to the …
Diabetic foot ulcers (DFUs), a leading cause of amputations, affect 15% of people with diabetes. A series of multiple mechanisms, including decreased cell and growth factor response, lead to diminished peripheral blood flow and decreased local angiogenesis, all of which can contribute to lack of healing in persons with DFUs. In this issue of the JCI, Gallagher and colleagues demonstrate that in diabetic mice, hyperoxia enhances the mobilization of circulating endothelial progenitor cells (EPCs) from the bone marrow to the peripheral circulation (see the related article beginning on page 1249). Local injection of the chemokine stromal cell–derived factor–1α then recruits these EPCs to the cutaneous wound site, resulting in accelerated wound healing. Thus, Gallagher et al. have identified novel potential targets for therapeutic intervention in diabetic wound healing.
The Journal of Clinical Investigation