High-efficiency postdilution online hemodiafiltration reduces all-cause mortality in hemodialysis patients

F Maduell, F Moreso, M Pons, R Ramos… - Journal of the …, 2013 - journals.lww.com
Retrospective studies suggest that online hemodiafiltration (OL-HDF) may reduce the risk of
mortality compared with standard hemodialysis in patients with ESRD. We conducted a
multicenter, open-label, randomized controlled trial in which we assigned 906 chronic
hemodialysis patients either to continue hemodialysis (n= 450) or to switch to high-efficiency
postdilution OL-HDF (n= 456). The primary outcome was all-cause mortality, and secondary
outcomes included cardiovascular mortality, all-cause hospitalization, treatment tolerability …