Lung collagen composition and synthesis: characterization and changes with age
KH Bradley, SD McConnell, RG Crystal - Journal of Biological Chemistry, 1974 - ASBMB
In the lung, collagen is found associated with bronchi, with blood vessels, and with the
alveolar interstitium; it is known to be fundamental in the maintenance of lung structure and
function. Two collagen chains, α 1 and α 2, can be extracted from rabbit lung homogenates;
each chain has an approximate molecular weight of 100,000 and is composed of amino
acids that are characteristic of collagen, but are not specific for lung. Lung slices incubated
in vitro synthesize α 1 and α 2 chains, as demonstrated by carboxymethylcellulose …
alveolar interstitium; it is known to be fundamental in the maintenance of lung structure and
function. Two collagen chains, α 1 and α 2, can be extracted from rabbit lung homogenates;
each chain has an approximate molecular weight of 100,000 and is composed of amino
acids that are characteristic of collagen, but are not specific for lung. Lung slices incubated
in vitro synthesize α 1 and α 2 chains, as demonstrated by carboxymethylcellulose …