Myeloid marker expression on antiviral CD8+ T cells following an acute virus infection
Y Lin, TJ Roberts, V Sriram, S Cho… - European journal of …, 2003 - Wiley Online Library
Y Lin, TJ Roberts, V Sriram, S Cho, RR Brutkiewicz
European journal of immunology, 2003•Wiley Online LibraryAbstract CD11b, CD11c, and F4/80 are normally used to define dendritic cell and/or
macrophage populations. In this study, the expression of all three markers was observed on
CD8+ T cells following infection of mice with several distinct viruses. Using lymphocytic
choriomeningitis virus as a model virus, it was found that relatively more CD11b+ CD8+ and
CD11c+ CD8+ T cells were present in the periphery than in primary lymphoid organs; in
contrast, the F4/80+ CD8+ T cell population was more prevalent in the spleen. All three …
macrophage populations. In this study, the expression of all three markers was observed on
CD8+ T cells following infection of mice with several distinct viruses. Using lymphocytic
choriomeningitis virus as a model virus, it was found that relatively more CD11b+ CD8+ and
CD11c+ CD8+ T cells were present in the periphery than in primary lymphoid organs; in
contrast, the F4/80+ CD8+ T cell population was more prevalent in the spleen. All three …
Abstract
CD11b, CD11c, and F4/80 are normally used to define dendritic cell and/or macrophage populations. In this study, the expression of all three markers was observed on CD8+ T cells following infection of mice with several distinct viruses. Using lymphocytic choriomeningitis virus as a model virus, it was found that relatively more CD11b+CD8+ and CD11c+CD8+ T cells were present in the periphery than in primary lymphoid organs; in contrast, the F4/80+CD8+ T cell population was more prevalent in the spleen. All three myeloid markers were detected on virus‐specific CTL. The expression of CD11b and CD11c on CD8+ T cells correlated with their level of CTL activity, whereas the F4/80+CD8+ T cell population increased after the peak of the CTL response but did not have higher CTL activity. These data suggest that there is a differential induction of CD11b, CD11c, and F4/80 on virus‐specific CD8+ T cells following an acute virus infection.
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