[HTML][HTML] Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): interaction of an α-helix of ChREBP with the 14-3-3 proteins …
H Sakiyama, RM Wynn, WR Lee, M Fukasawa… - Journal of biological …, 2008 - ASBMB
Carbohydrate response element-binding protein (ChREBP) is a glucose-responsive
transcription factor that plays a critical role in the glucose-mediated induction of gene
products involved in hepatic glycolysis and lipogenesis. Glucose affects the activity of
ChREBP largely through post-translational mechanisms involving phosphorylation-
dependent cellular localization. In this work we show that the N-terminal region of ChREBP
(residues 1-251) regulates its subcellular localization via an interaction with 14-3-3. 14-3-3 …
transcription factor that plays a critical role in the glucose-mediated induction of gene
products involved in hepatic glycolysis and lipogenesis. Glucose affects the activity of
ChREBP largely through post-translational mechanisms involving phosphorylation-
dependent cellular localization. In this work we show that the N-terminal region of ChREBP
(residues 1-251) regulates its subcellular localization via an interaction with 14-3-3. 14-3-3 …