Immune-mediated modulation of breast cancer growth and metastasis by the chemokine Mig (CXCL9) in a murine model
TC Walser, X Ma, N Kundu, R Dorsey… - Journal of …, 2007 - journals.lww.com
Current immunotherapies are limited by several factors, including the failure to recruit
sufficient numbers of immune effector cells to tumors. The chemokine monokine induced by
γ-interferon (Mig; CXCL9) attracts activated T cells and natural killer (NK) cells bearing the
chemokine receptor CXCR3. We investigated Mig as an immunotherapeutic agent in a
syngeneic murine model of metastatic breast cancer. We transfected the highly malignant
murine mammary tumor cell line 66.1 to stably express murine Mig cDNA. Immune …
sufficient numbers of immune effector cells to tumors. The chemokine monokine induced by
γ-interferon (Mig; CXCL9) attracts activated T cells and natural killer (NK) cells bearing the
chemokine receptor CXCR3. We investigated Mig as an immunotherapeutic agent in a
syngeneic murine model of metastatic breast cancer. We transfected the highly malignant
murine mammary tumor cell line 66.1 to stably express murine Mig cDNA. Immune …