Non-coding RNA production by RNA polymerase III is implicated in cancer
L Marshall, RJ White - Nature Reviews Cancer, 2008 - nature.com
L Marshall, RJ White
Nature Reviews Cancer, 2008•nature.comAbstract RNA polymerase III (Pol III) makes a variety of small non-coding RNAs, such as
tRNA and 5S ribosomal RNA. Increased expression of pol III products is often observed in
transformed cells. Much progress has been made in determining how Pol III-dependent
transcription is regulated and how it increases in cancers, but the importance of this increase
has not been clearly established. New evidence suggests that Pol III output can substantially
affect transformation.
tRNA and 5S ribosomal RNA. Increased expression of pol III products is often observed in
transformed cells. Much progress has been made in determining how Pol III-dependent
transcription is regulated and how it increases in cancers, but the importance of this increase
has not been clearly established. New evidence suggests that Pol III output can substantially
affect transformation.
Abstract
RNA polymerase III (Pol III) makes a variety of small non-coding RNAs, such as tRNA and 5S ribosomal RNA. Increased expression of pol III products is often observed in transformed cells. Much progress has been made in determining how Pol III-dependent transcription is regulated and how it increases in cancers, but the importance of this increase has not been clearly established. New evidence suggests that Pol III output can substantially affect transformation.
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