Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme

K Kuida, JA Lippke, G Ku, MW Harding, DJ Livingston… - science, 1995 - science.org
K Kuida, JA Lippke, G Ku, MW Harding, DJ Livingston, MSS Su, RA Flavell
science, 1995science.org
The interleukin-1β (IL-1β) converting enzyme (ICE) processes the inactive IL-1β precursor to
the proinflammatory cytokine. Adherent monocytes from mice harboring a disrupted ICE
gene (ICE-/-) did not export IL-1β or interleukin-1α (IL-1α) after stimulation with
lipopolysaccharide. Export of tumor necrosis factor-α and interleukin-6 (IL-6) from these cells
was also diminished. Thymocytes from ICE-/-mice were sensitive to apoptosis induced by
dexamethasone or ionizing radiation, but were resistant to apoptosis induced by Fas …
The interleukin-1β (IL-1β) converting enzyme (ICE) processes the inactive IL-1β precursor to the proinflammatory cytokine. Adherent monocytes from mice harboring a disrupted ICE gene (ICE-/-) did not export IL-1β or interleukin-1α (IL-1α) after stimulation with lipopolysaccharide. Export of tumor necrosis factor-α and interleukin-6 (IL-6) from these cells was also diminished. Thymocytes from ICE-/- mice were sensitive to apoptosis induced by dexamethasone or ionizing radiation, but were resistant to apoptosis induced by Fas antibody. Despite this defect in apoptosis, ICE-/- mice proceed normally through development.
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