[HTML][HTML] Sublytic membrane-attack-complex (MAC) activation alters regulated rather than constitutive vascular endothelial growth factor (VEGF) secretion in retinal …

K Kunchithapautham, B Rohrer - Journal of Biological Chemistry, 2011 - ASBMB
Uncontrolled activation of the alternative complement pathway and secretion of vascular
endothelial growth factor (VEGF) are thought to be associated with age-related macular
degeneration (AMD). Previously, we have shown that in RPE monolayers, oxidative-stress
reduced complement inhibition on the cell surface. The resulting increased level of sublytic
complement activation resulted in VEGF release, which disrupted the barrier facility of these
cells as determined by transepithelial resistance (TER) measurements. Induced rather than …