[PDF][PDF] Proteasomes in lungs from organ donors and patients with end-stage pulmonary diseases.
TA Baker, HH Bach Iv, RL Gamelli… - Physiological …, 2014 - pdfs.semanticscholar.org
TA Baker, HH Bach Iv, RL Gamelli, RB Love, M Majetschak
Physiological Research, 2014•pdfs.semanticscholar.orgProteasomes appear to be involved in the pathophysiology of various acute and chronic
lung diseases. Information on the human lung proteasome in health and disease, however,
is sparse. Therefore, we studied whether end-stage pulmonary diseases are associated with
alterations in lung 20S/26S proteasome content, activity and 20S subunit composition.
lung diseases. Information on the human lung proteasome in health and disease, however,
is sparse. Therefore, we studied whether end-stage pulmonary diseases are associated with
alterations in lung 20S/26S proteasome content, activity and 20S subunit composition.
Summary
Proteasomes appear to be involved in the pathophysiology of various acute and chronic lung diseases. Information on the human lung proteasome in health and disease, however, is sparse. Therefore, we studied whether end-stage pulmonary diseases are associated with alterations in lung 20S/26S proteasome content, activity and 20S subunit composition.
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