[HTML][HTML] Telomerase deficiency causes alveolar stem cell senescence-associated low-grade inflammation in lungs
R Chen, K Zhang, H Chen, X Zhao, J Wang, L Li… - Journal of Biological …, 2015 - ASBMB
Mutations of human telomerase RNA component (TERC) and telomerase reverse
transcriptase (TERT) are associated with a subset of lung aging diseases, but the
mechanisms by which TERC and TERT participate in lung diseases remain unclear. In this
report, we show that knock-out (KO) of the mouse gene Terc or Tert causes pulmonary
alveolar stem cell replicative senescence, epithelial impairment, formation of alveolar sacs,
and characteristic inflammatory phenotype. Deficiency in TERC or TERT causes a …
transcriptase (TERT) are associated with a subset of lung aging diseases, but the
mechanisms by which TERC and TERT participate in lung diseases remain unclear. In this
report, we show that knock-out (KO) of the mouse gene Terc or Tert causes pulmonary
alveolar stem cell replicative senescence, epithelial impairment, formation of alveolar sacs,
and characteristic inflammatory phenotype. Deficiency in TERC or TERT causes a …