Regulation of iron acquisition and storage: consequences for iron-linked disorders

I De Domenico, D McVey Ward, J Kaplan - Nature reviews Molecular …, 2008 - nature.com
I De Domenico, D McVey Ward, J Kaplan
Nature reviews Molecular cell biology, 2008nature.com
Mammalian iron homeostasis must be meticulously regulated so that this essential element
is available for use, but at the same time prevented from promoting the formation of toxic
radicals. Controlling the entry of iron into blood plasma is the main mechanism by which iron
stores in the body are physiologically manipulated and regulated. Defects in iron acquisition
at the cellular and systemic levels lead to human disorders, which involve either iron
overload or iron deficiency. Discoveries of iron transporters and insights into their regulation …
Abstract
Mammalian iron homeostasis must be meticulously regulated so that this essential element is available for use, but at the same time prevented from promoting the formation of toxic radicals. Controlling the entry of iron into blood plasma is the main mechanism by which iron stores in the body are physiologically manipulated and regulated. Defects in iron acquisition at the cellular and systemic levels lead to human disorders, which involve either iron overload or iron deficiency. Discoveries of iron transporters and insights into their regulation have provided important information about iron metabolism and genetic iron disorders.
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