[HTML][HTML] Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae

B Opitz, A Püschel, B Schmeck, AC Hocke… - Journal of Biological …, 2004 - ASBMB
Streptococcus pneumoniae, the major cause of community-acquired pneumonia and
bacterial meningitis, has been shown to transiently invade epithelial and endothelial cells.
Innate immune receptors including Toll-like receptors recognize various pathogens, such as
S. pneumoniae, by identifying conserved pathogen-associated molecular patterns. Recently,
two members of a novel class of pattern recognition receptors, the cytosolic proteins
nucleotide-binding oligomerization domain 1 (Nod1)/CARD4 and Nod2/CARD15, have …