Exploring HCN channels as novel drug targets

O Postea, M Biel - Nature reviews Drug discovery, 2011 - nature.com
O Postea, M Biel
Nature reviews Drug discovery, 2011nature.com
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have a key role in the
control of heart rate and neuronal excitability. Ivabradine is the first compound acting on
HCN channels to be clinically approved for the treatment of angina pectoris. HCN channels
may offer excellent opportunities for the development of novel anticonvulsant, anaesthetic
and analgesic drugs. In support of this idea, some well-established drugs that act on the
central nervous system—including lamotrigine, gabapentin and propofol—have been found …
Abstract
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have a key role in the control of heart rate and neuronal excitability. Ivabradine is the first compound acting on HCN channels to be clinically approved for the treatment of angina pectoris. HCN channels may offer excellent opportunities for the development of novel anticonvulsant, anaesthetic and analgesic drugs. In support of this idea, some well-established drugs that act on the central nervous system — including lamotrigine, gabapentin and propofol — have been found to modulate HCN channel function. This Review gives an up-to-date summary of compounds acting on HCN channels, and discusses strategies to further explore the potential of these channels for therapeutic intervention.
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