Treatment strategies and clinical trial design in ADPKD

VE Torres - Advances in chronic kidney disease, 2010 - Elsevier
More frequent utilization and continuous improvement of imaging techniques has enhanced
appreciation of the high phenotypic variability of autosomal dominant polycystic kidney
disease, improved understanding of its natural history, and facilitated the observation of its
structural progression. At the same time, identification of the PKD1 and PKD2 genes has
provided clues to how the disease develops when they (genetic mechanisms) and their
encoded proteins (molecular mechanisms) are disrupted. Interventions designed to rectify …