TGFβ signals through a heteromeric protein kinase receptor complex

JL Wrana, L Attisano, J Cárcamo, A Zentella, J Doody… - Cell, 1992 - cell.com
JL Wrana, L Attisano, J Cárcamo, A Zentella, J Doody, M Laiho, XF Wang, J Massague
Cell, 1992cell.com
Transforming growth factor p (TGFfl) binds with high affinity to the type II receptor, a
transmembrane protein with a cytoplasmic serine/threonine kinase domain. We show that
the type II receptor requires both its kinase activity and association with another
TGFgbinding protein, the type I receptor, to signal growth inhibition and early gene
responses. Receptors I and II associate as interdependent components of a heteromerit
complex: receptor I requires receptor II to bind TGFf3, and receptor II requires receptor I to …
Summary
Transforming growth factor p (TGFfl) binds with high affinity to the type II receptor, a transmembrane protein with a cytoplasmic serine/threonine kinase domain. We show that the type II receptor requires both its kinase activity and association with another TGFgbinding protein, the type I receptor, to signal growth inhibition and early gene responses. Receptors I and II associate as interdependent components of a heteromerit complex: receptor I requires receptor II to bind TGFf3, and receptor II requires receptor I to signal. This mode of operation points to fundamental differences between this receptor and the protein-tyrosine kinase cytokine receptors.
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