Alloreactivity from human viral specific memory T-cells
LJA D'Orsogna, DL Roelen, IIN Doxiadis… - Transplant …, 2010 - Elsevier
The mechanisms by which alloreactive memory T-cells are generated in non-sensitized
individuals have begun to be elucidated. It is generally accepted that a very high level of
crossreactivity is an essential feature of the T-cell receptor. Indeed it has recently been
shown that alloreactivity from viral specific memory T-cells is far more common than
predicted, 45% of viral specific T-cell clones were found to be allo-HLA crossreactive. In this
overview the evidence for crossreactive alloresponses from human viral specific memory T …
individuals have begun to be elucidated. It is generally accepted that a very high level of
crossreactivity is an essential feature of the T-cell receptor. Indeed it has recently been
shown that alloreactivity from viral specific memory T-cells is far more common than
predicted, 45% of viral specific T-cell clones were found to be allo-HLA crossreactive. In this
overview the evidence for crossreactive alloresponses from human viral specific memory T …