It was found recently that a diabetes-associated protein in insulin-sensitive tissue (DAPIT) is
associated with mitochondrial ATP synthase. Here, we report that the suppressed
expression of DAPIT in DAPIT-knockdown HeLa cells causes loss of the population of ATP
synthase in mitochondria. Consequently, DAPIT-knockdown cells show smaller
mitochondrial ATP synthesis activity, slower growth in normal medium, and poorer viability in
glucose-free medium than the control cells. The mRNA levels of α-and β-subunits of ATP …