[HTML][HTML] Factor VIII and von Willebrand factor are ligands for the carbohydrate-receptor Siglec-5
JN Pegon, M Kurdi, C Casari, S Odouard… - …, 2012 - ncbi.nlm.nih.gov
JN Pegon, M Kurdi, C Casari, S Odouard, CV Denis, OD Christophe, PJ Lenting
Haematologica, 2012•ncbi.nlm.nih.govBackground Factor VIII (FVIII) and von Willebrand factor (VWF) circulate in plasma in a tight
non-covalent complex, being critical to hemostasis. Although structurally unrelated, both
share the presence of sialylated glycan-structures, making them potential ligands for sialic-
acid-binding-immunoglobulin-like-lectins (Siglecs).
non-covalent complex, being critical to hemostasis. Although structurally unrelated, both
share the presence of sialylated glycan-structures, making them potential ligands for sialic-
acid-binding-immunoglobulin-like-lectins (Siglecs).
Abstract
Background
Factor VIII (FVIII) and von Willebrand factor (VWF) circulate in plasma in a tight non-covalent complex, being critical to hemostasis. Although structurally unrelated, both share the presence of sialylated glycan-structures, making them potential ligands for sialic-acid-binding-immunoglobulin-like-lectins (Siglecs).
ncbi.nlm.nih.gov
