IFN-γ and CD25 drive distinct pathologic features during hemophagocytic lymphohistiocytosis
S Humblet-Baron, D Franckaert, J Dooley, F Ailal… - Journal of Allergy and …, 2019 - Elsevier
Background Inflammatory activation of CD8+ T cells can, when left unchecked, drive severe
immunopathology. Hyperstimulation of CD8+ T cells through a broad set of triggering
signals can precipitate hemophagocytic lymphohistiocytosis (HLH), a life-threatening
systemic inflammatory disorder. Objective The mechanism linking CD8+ T-cell
hyperactivation to pathology is controversial, with excessive production of IFN-γ and, more
recently, excessive consumption of IL-2, which are proposed as competing hypotheses. We …
immunopathology. Hyperstimulation of CD8+ T cells through a broad set of triggering
signals can precipitate hemophagocytic lymphohistiocytosis (HLH), a life-threatening
systemic inflammatory disorder. Objective The mechanism linking CD8+ T-cell
hyperactivation to pathology is controversial, with excessive production of IFN-γ and, more
recently, excessive consumption of IL-2, which are proposed as competing hypotheses. We …
