Three-dimensional structure of recombinant human interferon-γ
SE Ealick, WJ Cook, S Vijay-Kumar, M Carson… - Science, 1991 - science.org
SE Ealick, WJ Cook, S Vijay-Kumar, M Carson, TL Nagabhushan, PP Trotta, C Bugg
Science, 1991•science.orgThe x-ray crystal structure of recombinant human interferon-γ has been determined with the
use of multiple-isomorphous-replacement techniques. Interferon-γ, which is dimeric in
solution, crystallizes with two dimers related by a noncrystallographic twofold axis in the
asymmetric unit. The protein is primarily α helical, with six helices in each subunit that
comprise∼ 62 percent of the structure; there is no β sheet. The dimeric structure of human
interferon-γ is stabilized by the intertwining of helices across the subunit interface with …
use of multiple-isomorphous-replacement techniques. Interferon-γ, which is dimeric in
solution, crystallizes with two dimers related by a noncrystallographic twofold axis in the
asymmetric unit. The protein is primarily α helical, with six helices in each subunit that
comprise∼ 62 percent of the structure; there is no β sheet. The dimeric structure of human
interferon-γ is stabilized by the intertwining of helices across the subunit interface with …
The x-ray crystal structure of recombinant human interferon-γ has been determined with the use of multiple-isomorphous-replacement techniques. Interferon-γ, which is dimeric in solution, crystallizes with two dimers related by a noncrystallographic twofold axis in the asymmetric unit. The protein is primarily α helical, with six helices in each subunit that comprise ∼62 percent of the structure; there is no β sheet. The dimeric structure of human interferon-γ is stabilized by the intertwining of helices across the subunit interface with multiple intersubunit interactions.
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