Increased activity of the complement system in the liver of patients with alcoholic hepatitis
H Shen, BA French, H Liu, BC Tillman… - … and molecular pathology, 2014 - Elsevier
Inflammation has been suggested as a mechanism underlying the development of alcoholic
hepatitis (AH). The activation of the complement system plays an important role in
inflammation. Although it has been shown that ethanol-induced activation of the complement
system contributes to the pathophysiology of ethanol-induced liver injury in mice, whether
ethanol consumption activates the complement system in the human liver has not been
investigated. Using antibodies against C1q, C3, and C5, the immunoreactivity of the …
hepatitis (AH). The activation of the complement system plays an important role in
inflammation. Although it has been shown that ethanol-induced activation of the complement
system contributes to the pathophysiology of ethanol-induced liver injury in mice, whether
ethanol consumption activates the complement system in the human liver has not been
investigated. Using antibodies against C1q, C3, and C5, the immunoreactivity of the …