[HTML][HTML] A role for the human nucleotide-binding domain, leucine-rich repeat-containing family member NLRC5 in antiviral responses
A Neerincx, K Lautz, M Menning, E Kremmer… - Journal of biological …, 2010 - ASBMB
Proteins of the nucleotide-binding domain, leucine-rich repeat (NLR)-containing family
recently gained attention as important components of the innate immune system. Although
over 20 of these proteins are present in humans, only a few members including the cytosolic
pattern recognition receptors NOD1, NOD2, and NLRP3 have been analyzed extensively.
These NLRs were shown to be pivotal for mounting innate immune response toward
microbial invasion. Here we report on the characterization of human NLRC5 and provide …
recently gained attention as important components of the innate immune system. Although
over 20 of these proteins are present in humans, only a few members including the cytosolic
pattern recognition receptors NOD1, NOD2, and NLRP3 have been analyzed extensively.
These NLRs were shown to be pivotal for mounting innate immune response toward
microbial invasion. Here we report on the characterization of human NLRC5 and provide …
