[HTML][HTML] Vendor-specific microbiome controls both acute and chronic murine lung allograft rejection by altering CD4+ Foxp3+ regulatory T cell levels
Despite standardized postoperative care, some lung transplant patients suffer multiple
episodes of acute and chronic rejection while others avoid graft problems for reasons that
are poorly understood. Using an established model of C57BL/10 to C57BL/6 minor antigen
mismatched single lung transplantation, we now demonstrate that the recipient microbiota
contributes to variability in the alloimmune response. Specifically, mice from the Envigo
facility in Frederick, Maryland contain nearly double the number of CD4+ Foxp3+ regulatory …
episodes of acute and chronic rejection while others avoid graft problems for reasons that
are poorly understood. Using an established model of C57BL/10 to C57BL/6 minor antigen
mismatched single lung transplantation, we now demonstrate that the recipient microbiota
contributes to variability in the alloimmune response. Specifically, mice from the Envigo
facility in Frederick, Maryland contain nearly double the number of CD4+ Foxp3+ regulatory …