• A quantitative and clinically correlated investigation was carried out to determine the
divisional distribution of volumetric and cell-packing density changes in the amygdala in
patients with advanced aging and senile dementia. Normal controls show relatively little, but
nevertheless significant, age-related change. In contrast, the amygdala undergoes very
marked degeneration in patients with senile dementia, which preferentially affects the
morphologically, developmentally, and connectionally older medial, medial central, and …