BACKGROUND: Atopic dermatitis (AD) and psoriasis are common inflammatory diseases
canonically described as involving distinct TH polarization and granulocytic infiltration. Acute
AD lesions are associated with TH2 and eosinophilic inflammation, whereas psoriatic
lesions are associated with TH1/TH17 and neutrophilic inflammation. Despite intensive
investigation, these pathways remain incompletely understood in vivo in human subjects.
OBJECTIVE: Using AD and psoriatic lesional skin as exemplar TH2 and TH1/TH17 diseased …