MicroRNA-146a suppresses IL-17–mediated skin inflammation and is genetically associated with psoriasis
A Srivastava, P Nikamo, W Lohcharoenkal, D Li… - Journal of Allergy and …, 2017 - Elsevier
Background Psoriasis is an immune-mediated inflammatory skin disease with a strong
genetic background in which activation of IL-17 signaling is central in the pathogenesis.
Little has been known about the role of noncoding RNAs, including microRNAs (miRNAs), in
predisposition to the disease. Objective We sought to investigate the genetic association of
single nucleotide polymorphisms in microRNA-146a (miR-146a) to psoriasis and to explore
its function in the initiation and resolution of the disease. Methods Analysis of the genetic …
genetic background in which activation of IL-17 signaling is central in the pathogenesis.
Little has been known about the role of noncoding RNAs, including microRNAs (miRNAs), in
predisposition to the disease. Objective We sought to investigate the genetic association of
single nucleotide polymorphisms in microRNA-146a (miR-146a) to psoriasis and to explore
its function in the initiation and resolution of the disease. Methods Analysis of the genetic …