[HTML][HTML] Regulation of O2 consumption by the PI3K and mTOR pathways contributes to tumor hypoxia
Background Inhibitors of the phosphatidylinositol 3-kinase (PI3K) and the mammalian target
of rapamycin (mTOR) pathway are currently in clinical trials. In addition to antiproliferative
and proapoptotic effects, these agents also diminish tumor hypoxia. Since hypoxia is a major
cause of resistance to radiotherapy, we sought to understand how it is regulated by
PI3K/mTOR inhibition. Methods Whole cell, mitochondrial, coupled and uncoupled oxygen
consumption were measured in cancer cells after inhibition of PI3K (Class I) and mTOR by …
of rapamycin (mTOR) pathway are currently in clinical trials. In addition to antiproliferative
and proapoptotic effects, these agents also diminish tumor hypoxia. Since hypoxia is a major
cause of resistance to radiotherapy, we sought to understand how it is regulated by
PI3K/mTOR inhibition. Methods Whole cell, mitochondrial, coupled and uncoupled oxygen
consumption were measured in cancer cells after inhibition of PI3K (Class I) and mTOR by …
