[HTML][HTML] Inositol 1, 4, 5-trisphosphate (IP3) receptor up-regulation in hypertension is associated with sensitization of Ca2+ release and vascular smooth muscle …
Resistance arteries show accentuated responsiveness to vasoconstrictor agonists in
hypertension, and this abnormality relies partly on enhanced Ca 2+ signaling in vascular
smooth muscle (VSM). Although inositol 1, 4, 5-triphosphate receptors (IP 3 Rs) are
abundant in VSM, their role in the molecular remodeling of the Ca 2+ signaling machinery
during hypertension has not been addressed. Therefore, we compared IP 3 R expression
and function between mesenteric arteries of normotensive and hypertensive animals. Levels …
hypertension, and this abnormality relies partly on enhanced Ca 2+ signaling in vascular
smooth muscle (VSM). Although inositol 1, 4, 5-triphosphate receptors (IP 3 Rs) are
abundant in VSM, their role in the molecular remodeling of the Ca 2+ signaling machinery
during hypertension has not been addressed. Therefore, we compared IP 3 R expression
and function between mesenteric arteries of normotensive and hypertensive animals. Levels …