[HTML][HTML] Regulation of the type 1 inositol 1, 4, 5-trisphosphate receptor by phosphorylation at tyrosine 353
J Cui, SJ Matkovich, N deSouza, S Li… - Journal of Biological …, 2004 - ASBMB
The inositol 1, 4, 5-trisphosphate receptor (IP 3 R) plays an essential role in Ca 2+ signaling
during lymphocyte activation. Engagement of the T cell or B cell receptor by antigen initiates
a signal transduction cascade that leads to tyrosine phosphorylation of IP 3 R by Src family
nonreceptor protein tyrosine kinases, including Fyn. However, the effect of tyrosine
phosphorylation on the IP 3 R and subsequent Ca 2+ release is poorly understood. We have
identified tyrosine 353 (Tyr 353) in the IP 3-binding domain of type 1 IP 3 R (IP 3 R1) as a …
during lymphocyte activation. Engagement of the T cell or B cell receptor by antigen initiates
a signal transduction cascade that leads to tyrosine phosphorylation of IP 3 R by Src family
nonreceptor protein tyrosine kinases, including Fyn. However, the effect of tyrosine
phosphorylation on the IP 3 R and subsequent Ca 2+ release is poorly understood. We have
identified tyrosine 353 (Tyr 353) in the IP 3-binding domain of type 1 IP 3 R (IP 3 R1) as a …