[HTML][HTML] Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells
F Spitzenberger, S Pietropaolo, P Verkade… - Journal of Biological …, 2003 - ASBMB
Islet cell autoantigen of 69 kDa (ICA69) is a cytosolic protein of still unknown function.
Involvement of ICA69 in neurosecretion has been suggested by the impairment of
acetylcholine release at neuromuscular junctions upon mutation of its homologue gene ric-
19 in C. elegans. In this study, we have further investigated the localization of ICA69 in
neurons and insulinoma INS-1 cells. ICA69 was enriched in the perinuclear region, whereas
it did not co-localize with markers of synaptic vesicles/synaptic-like microvesicles. Confocal …
Involvement of ICA69 in neurosecretion has been suggested by the impairment of
acetylcholine release at neuromuscular junctions upon mutation of its homologue gene ric-
19 in C. elegans. In this study, we have further investigated the localization of ICA69 in
neurons and insulinoma INS-1 cells. ICA69 was enriched in the perinuclear region, whereas
it did not co-localize with markers of synaptic vesicles/synaptic-like microvesicles. Confocal …