Dense-core secretory granule biogenesis
T Kim, MC Gondré-Lewis, I Arnaoutova… - Physiology, 2006 - journals.physiology.org
T Kim, MC Gondré-Lewis, I Arnaoutova, YP Loh
Physiology, 2006•journals.physiology.orgThe dense-core secretory granule is a key organelle for secretion of hormones and
neuropeptides in endocrine cells and neurons, in response to stimulation. Cholesterol and
granins are critical for the assembly of these organelles at the trans-Golgi network, and their
biogenesis is regulated quantitatively by posttranscriptional and posttranslational
mechanisms.
neuropeptides in endocrine cells and neurons, in response to stimulation. Cholesterol and
granins are critical for the assembly of these organelles at the trans-Golgi network, and their
biogenesis is regulated quantitatively by posttranscriptional and posttranslational
mechanisms.
The dense-core secretory granule is a key organelle for secretion of hormones and neuropeptides in endocrine cells and neurons, in response to stimulation. Cholesterol and granins are critical for the assembly of these organelles at the trans-Golgi network, and their biogenesis is regulated quantitatively by posttranscriptional and posttranslational mechanisms.
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