The role of Ca2+ activated Cl− channels in blood pressure control
VV Matchkov, DM Boedtkjer, C Aalkjaer - Current Opinion in Pharmacology, 2015 - Elsevier
Highlights•CaCCs represent a heterologous group of proteins, for example, TMEM16A and
bestrophins.•CaCCs are important for kidney cyst proliferation and cyst fluid
secretion.•CaCCs are important for maintaining fluid, electrolyte and acid–base
balance.•CaCCs play a role in repolarization of the cardiac action potential.•CaCCs are
important for the amplification of Ca 2+ influx and contraction in VSMCs.Ca 2+-activated Cl−
channels (CaCCs) have numerous functions in the body and are potential players in the …
bestrophins.•CaCCs are important for kidney cyst proliferation and cyst fluid
secretion.•CaCCs are important for maintaining fluid, electrolyte and acid–base
balance.•CaCCs play a role in repolarization of the cardiac action potential.•CaCCs are
important for the amplification of Ca 2+ influx and contraction in VSMCs.Ca 2+-activated Cl−
channels (CaCCs) have numerous functions in the body and are potential players in the …