[HTML][HTML] MST1 promotes apoptosis through phosphorylation of histone H2AX
W Wen, F Zhu, J Zhang, YS Keum, T Zykova… - Journal of Biological …, 2010 - ASBMB
MST1 (mammalian STE20-like kinase 1) is a serine/threonine kinase that is cleaved and
activated by caspases during apoptosis. Overexpression of MST1 induces apoptotic
morphological changes such as chromatin condensation, but the mechanism is not clear.
Here we show that MST1 induces apoptotic chromatin condensation through its
phosphorylation of histone H2AX at Ser-139. During etoposide-induced apoptosis in Jurkat
cells, the cleavage of MST1 directly corresponded with strong H2AX phosphorylation. In vitro …
activated by caspases during apoptosis. Overexpression of MST1 induces apoptotic
morphological changes such as chromatin condensation, but the mechanism is not clear.
Here we show that MST1 induces apoptotic chromatin condensation through its
phosphorylation of histone H2AX at Ser-139. During etoposide-induced apoptosis in Jurkat
cells, the cleavage of MST1 directly corresponded with strong H2AX phosphorylation. In vitro …