Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression
JN Bae, JR MacFall, KRR Krishnan, ME Payne… - Biological …, 2006 - Elsevier
BACKGROUND: The dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex
(ACC) are critical for mood regulation. Alterations in the white matter connections of these
regions may impair their role in mood regulation and increase the risk of developing
depression. This study used diffusion tensor imaging to examine for white matter
microstructural abnormalities of these regions and of central white matter structures in late-
life depression. METHODS: One hundred six elderly depressed subjects and eighty-four …
(ACC) are critical for mood regulation. Alterations in the white matter connections of these
regions may impair their role in mood regulation and increase the risk of developing
depression. This study used diffusion tensor imaging to examine for white matter
microstructural abnormalities of these regions and of central white matter structures in late-
life depression. METHODS: One hundred six elderly depressed subjects and eighty-four …